More “Bad News, Period”

Congestive heart failure: more bad news from exercising muscle?

A key question, then, is are these maladaptations related or are they merely a summation of physiological “bad luck” associated with poor cardiac function and the resultant physical inactivity? Over the past 20 years one revolutionary idea has been that “overactivation” of the sympathetic nervous system in CHF makes a bad situation worse and broadly contributes to a downward spiral in many elem...

Selenium and diabetes: more bad news for supplements.

In this issue, Stranges and colleagues (1) report findings from the Nutritional Prevention of Cancer (NPC) trial that show an increased risk for diabetes among participants randomly assigned to receive supplements with 200 g of selenium daily for 7.7 years compared with placebo. This effect was largely limited to participants in the top tertile of plasma selenium level at baseline ( 121.6 ng/mL...

Asbestos and Autoimmunity: More Bad News from Libby?

Recent studies on chromosome conformation show that chromosomes colocalize in the nucleus, bringing together active genes in transcription factories. This spatial proximity of actively transcribing genes could provide a means for RNA interaction at the transcript level. We have screened public databases for chimeric EST and mRNA sequences with the intent of mapping transcription-induced interch...

hiv/aids good news and bad news

Breaking bad news.